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Pro-inflammatory cytokines such as tumour necrosis factor beta (TNF), interferon alpha (IFN), interleukin-1 (IL-1), IL-5, and IL-16 are found upregulated, whereas the anti-inflammatory cytokines IL-4 and IL-13 are downregulated, resulting in an inflammatory process that causes neuronal damage and contributes to ADHD symptomatology [60]

TRF also significantly increased the concentration of -hydroxybutyrate (-HB), an endogenous inhibitor of histone deacetylases (HDACs)

Metformin is approved by the FDA as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

Nadia Corrinne Wojcik, sophomore, Deans List, College of Agricultural Sciences and Natural Resources, fisheries and wildlife

3c, d) showed significant correlations between several metabolites, both within and between pathways forming clusters of interacting molecules