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In atherosclerotic lesions, ATF3 mediated inhibition of M1 polarization reduces inflammatory responses and lowers the risk of plaque rupture

These findings reinforce the value of immune-centric systems biology frameworks for understanding disease heterogeneity and informing future immune-oriented stratification and therapeutic exploration

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Lip-1 Lip-1, a derivative of quinoxaline spirocyclic compounds, is a potent ferroptosis inhibitor first identified in 2014 through small molecule compound library screening (129)

The assessment of additional epigenetic and biochemical markers could also provide deeper insights into the observed differences between groups, ultimately contributing to the development of more effective and personalized intervention strategies