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[DOI] [PubMed] [Google Scholar] 146

In theory the pro-inflammatory cytokines are intended to mitigate infection, but with chronic inflammation the integrity of the cervicovaginal epithelial barrier can be compromised and increase the risk of acquiring STIs and of preterm birth 89,90

Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47 phox in recognition of a polyproline type II helix and an adjacent -helix of p22 phox