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Description

Hepatology 65 , 13061318 (2017)

doi:10.3390/nu5061962 Lem DW, Gierhart DL, Davey PG

Addressing the limitations of current nanoparticle-based cancer therapeutics, Shao and colleagues designed a system that encapsulated the hypoxia-activated prodrug tirapazamine (TPZ) within the porous structure of upconversion nanoparticles (UCNP)/MOFs nanocomposites, facilitating a synergistic treatment of PDT, hypoxia-activated chemotherapy, and immunotherapy triggered by NIR light (Shao et al., 2020)