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A deficiency in sirtuin 7 (SIRT7) and histone methylation patterns like H3K9me2 and H3K27me3, for example, can activate the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)-stimulator of interferon genes pathway, a well-recognized aging-associated signaling pathway, thus exacerbating the aging process

Akathisia is also implicit in the description of the symptoms of the very prevalent sensorimotor disorder RLS, where, more often, the sensory experience is an urgent need to specifically move ones legs (106)

Population dynamics of inherited copper toxicosis in Dutch Bedlington Terriers (1977-1997) J Vet Intern Med

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doi: 10.1111/j.1532-950X.2003.00515.x