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In some clinical studies, chronically-elevated leptin levels are associated with overeating, obesity, and, as mentioned above, metabolic diseases, including hypertension, diabetes, heart disease, and metabolic syndrome

Furthermore, microgravity conditions alter the production of short-chain fatty acids (SCFA) by microbes, impairing the digestion and absorption of nutrients during deeper space missions (Turroni et al

Potential Complications Patients who are diagnosed with ulcerative colitis have a higher risk of contracting colorectal cancer

Surgery success rates are generally good for pain relief (70 to 90% improvement in leg pain symptoms), but come with risks: infection, nerve damage, disc reherniation (5 to 15% recurrence rate after microdiscectomy), and adjacent segment disease with fusion (20 to 30% develop problems within 10 years)

doi:10.3399/bjgp22X719933