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Think of NNMT as a sort of cellular brake pedal on metabolism

Wang Z, Deng Q, Gu Y, Li M, Chen Y, Wang J, et al

This is mainly regulated by the interaction of Nrf2 with Keap1 [3537]

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8.2 Ferroptosis exacerbates central inflammation Neuroinflammation is primarily initiated by astrocytes and microglia in response to factors such as injury, infection, exposure to toxins, or autoimmune reactions