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Similar content being viewed by others Introduction Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing a broad spectrum of disorders such as atherosclerosis, ischemic heart disease, heart failure, cardiomyopathies, hypertension, pulmonary arterial hypertension, stroke, and aortic dissection-that together account for nearly one-third of all deaths worldwide [1]

10.1021/bi200810j Callahan BP, Topilina NI, Stanger MJ, Van Roey P, Belfort M: Structure of catalytically competent intein caught in a redox trap with functional and evolutionary implications

42,44 Additionally, pyruvate kinase (PK) is another crucial regulatory enzyme in glycolysis, with its activity positively regulated by acetyl-CoA and F1,6BP, while ATP and pyruvate exert negative feedback inhibition

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