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Furthermore, the presence of abnormal metabolites influences the functionality and maturation of cellular mitochondria, leading to the persistent release of pro-inflammatory cytokines, neurodegeneration, and demyelination, ultimately affecting the progression of MS

[19] Because of its antioxidant role, GSS mostly produce GSH inside the cytoplasm of liver cells and imported to mitochondria where detoxification occurs

Then, 25 L of water was added, and the sample was homogenized with zirconium oxide beads for 3 minutes, then 120 L of methanol containing an internal standard was added to extract the metabolites

Free Radical Biol Med 95:2742 Curtis PS, Luchli A (1985) Responses of kenaf to salt stress: germination and vegetative growth 1

Anticancer Agents Med Chem 2013