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Physical exercise of low/moderate intensity can often have positive effects and can be considered as a method of non-pharmacological intervention in inflammatory bowel disease (Ordille and Phadtare, 2023)

FIGURE 1 FIGURE 2 Individual-centric spheroids did not show cell over proliferation in long-term cell culture conditions The use of immortalized cell lines such as HepG2 or Huh7 to generate spheroids for DILI assessment often suffers from excessive uncontrolled cell proliferation resulting in enlarged spheroids with a necrotic core that can alter drug penetration and drug responses and thereby reducing the physiological relevance and predictive accuracy of the model