Disclosures: Zayed Rashid: Nothing to Disclose, Selamawit Woldesenbet: Nothing to Disclose, Mujtaba Khalil: Nothing to Disclose, Sidharth Iyer: Nothing to Disclose, Muhammad Muntazir Mehdi Khan: Nothing to Disclose, Muhammad Musaab Munir: Nothing to Disclose, Abdullah Altaf: Nothing to Disclose, Giovanni Catalano: Nothing to Disclose, Khalid Mumtaz: Nothing to Disclose, Timothy Pawlik: Nothing to Disclose 2643 HIGHLY SENSITIVE HEPATITIS B CORE-RELATED ANTIGEN (HBCRAG) MEASUREMENTS CAN PREDICT HEPATOCELLULAR CARCINOMA (HCC) RISK AND HEPATITIS B SURFACE ANTIGEN (HBSAG) LOSS IN HBEAG-NEGATIVE CHRONIC HEPATITIS B PATIENTS Tetsuya Hosaka 1 Fumitaka Suzuki 1 Mariko Kobayashi 1 Shunichiro Fujiyama 1 Yusuke Kawamura 1 Hitomi Sezaki 1 Norio Akuta 1 Yoshiyuki Suzuki 1 Satoshi Saitoh 1 Yasuji Arase 1 Hiromitsu Kumada 1 , 1 Toranomon Hospital Background: Serum hepatitis B core-related antigen (HBcrAg) has been known as surrogate markers of intrahepatic covalently closed circular DNA (cccDNA) and transcriptional activity

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