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In dietinduced obese mice, NNMTi treatment significantly reduced liver weight, liver volume, and hepatic triglyceride levels, alleviated hepatic steatosis and inflammatory infiltration, downregulated inflammatory factors (such as TNF and IL6) and lipogenic genes (such as FAS), and upregulated lipolytic genes (such as ATGL) in the liver

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Consistent with the Garcia scores, the vitamin B12-treated groups showed less tissue damage and neuronal apoptosis (Figure 1D), indicating that vitamin B12 reduced tissue damage, protected neurons in the cortex and ameliorated the pathological morphology of the lesion area after TBI in mice

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Pellissier et al