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In diet-induced obesity animal models, NNMT inhibition demonstrated metabolic changes including alterations in adipocyte lipid content without affecting food intake patterns, coupled with significant reductions in white adipose tissue mass in treated mice

When dieting, a B12 deficiency can occur due to the limitation of consumption of foods that are high in B12, such as red meat

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Vitamin B12 deficiency may occur in individuals with poor dietary intake, certain gastrointestinal disorders, malabsorption syndromes, advancing age, or as a consequence of some medications that reduce Vitamin B12 absorption

This role is related to the synthesis of neurodehyda, and maintains the completeness of sheath nerve fiber function