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After ketorolac tromethamine ophthalmic solution use, reports of bronchospasm or exacerbation of asthma exist among patients who have either a known hypersensitivity to aspirin/nonsteroidal anti-inflammatory drugs or a past medical history of asthma

First, it may itself activate or inactivate a drug and second, make a toxic compound more soluble, thereby facilitating its excretion in the urine or feces

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Clinically, such disturbances can manifest as cardiac dysfunction following acute psychological stress or a brain injury such as acute ischaemic stroke, or as cognitive disorders in patients with acute or chronic heart disease