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For OTA, the Klaassen equation has been used to estimate the continuous exposure to OTA based on blood plasma concentrations, and assumptions for plasma clearance and bioavailability (details in Duarte et al

J Mar Sci Eng 8(10):789 Khayyal MT et al (2024) Comparative pharmacokinetic study of standard Astaxanthin and its micellar formulation in healthy male volunteers

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In 8 out of 10 countries investigated in that study (Vicedo-Cabrera et al., 2018), the fraction of deaths attributable to heat declined over time, and this decline was due mostly to decreased sensitivity to heat (i.e., not local cooling)

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