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Initially the imidazoles clotrimazole (containing 4 five membered organic ring and one chloride molecule), econazole (containing 3 five membered organic ring and three chloride molecule), miconazole (containing 3 five membered organic ring and 4 chloride molecule) were discovered but due to their toxicity on the host body they were utilized as topical administration as an alternative to nystatin to treat cutaneous and mucocutaneous

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There is some concern that sodium benzoate can convert into the carcinogenic molecule benzene

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