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More discomfort Intramuscular injections typically require larger needles, which can be more difficult to self-administer and often cause more irritation

doi: 10.3389/fnins.2020.00042 145 CaiZYinKLiuQLiuMYangXCuiL

Finally, the control group received no topical treatment

Different from GSH-TPGS, GSH-PEG employed GSHs thiol group ( S -terminal) for linkage to PEG to form a thioether bond instead of an ester bond derived from the C -terminal linkage of the glycine carboxylic acid in GSH-TPGS

in oil (fatty oils or fatty acid esters, in particular C6-C32 fatty acid C2-C30 esters) or silicone oil, dispersion, suspension, creme, lotion or milk, depending on the production method and ingredients, a gel (including hydrogel, hydrodispersion gel, oleogel), spray (e.g