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Interestingly, CBS is upregulated by transcription factors such as nuclear factor erythroid 2-related factor 2 (NRF2) 17 , SP1/3 18 , and NFY 18 and its upregulation confers resistance against ferroptosis in ovarian cancer cells 17

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Understanding these mechanisms provides valuable insights that could be applied to the study of IFV

933 These results suggest that PPM1K mediates the disturbance of BCAA metabolism, regulates cerebral I/R injury by activating neuronal ferroptosis, and may serve as a therapeutic intervention target