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Bouchareb A, Le Cam A, Montfort J, Gay S, Nguyen T, Bobe J, et al

This review attempts to provide some mechanistic insight (Figures 13) into how the bi-directional network between the gut microbiota and the brain can not only protect but also trigger and aid chronic gut inflammation, promote a global pro-inflammatory state, modify and contribute to protein misfolding processes, dysregulate the autophagic-lysosomal protein clearance mechanism, differentiate T-cell subsets to facilitate a deleterious autoimmune response, and finally modulate immune recruitment and BBB status

The ongoing process causes inflammation (g) in the surrounding areas and the formation of scar tissue, which usually distorts the anatomy of the surrounding organs and interferes with their functions

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