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Biochemistry 52 , 57465759 (2013)

4-HNE preferentially forms adducts with cysteine residues of thiol-containing proteins, a number of which are proteins involved in redox signaling (39) (Fig

10.1182/blood.2019004158 Blood 270 YunJ.MullarkyE.LuC.BoschK

On the other hand, a negative attitude, violence, poor relationships, internal mental stress, all promote increased production of pro-inflammatory cytokines which activate the TH-17 pathway and promote autoimmunity