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The CAS acknowledged these observations in its findings, noting that they carried no weight as evidence but describing them as "at least not inconsistent" with the timeline of the program

Current data suggests that this affects around 1 in 10 people aged 75 or over, and 1 in 20 people aged 65 to 74 in the UK

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Tirzepatide's safety profile in clinical trials extending beyond one year supports the absence of problematic accumulation, with adverse events remaining consistent rather than increasing in frequency or severity over time

doi: 10.1039/D1NR03288G 95 XiangQYangCLuoYLiuFZhengJLiuWet al