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It is a cluster of overlapping biological dysfunctions that conventional medicines organ-by-organ approach is poorly equipped to address simultaneously

Oxidative DNA adducts such as 8-oxoG are not only lesions but also contextual signals that recruit base-excision machinery (e.g., OGG1) and remodel local chromatin, thereby coupling genome surveillance to transcriptional tuning

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Pharmacol Rep 72(5):11951217 Mahato AK, Sidorova YA (2020) Glial cell line-derived neurotrophic factors (GFLs) and small molecules targeting RET receptor for the treatment of pain and Parkinsons disease