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Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that, upon activation, translocates to the nucleus and binds antioxidant response elements (AREs) in DNA to drive expression of antioxidant genes

GR is another critical enzyme involved in antioxidant defense and responsible for reducing GSSG back to its reduced form GSH, which is pivotal for the cellular antioxidant protection 53

Albumin binding sites 5.1

The decreased tumour growth in this model is likely due to the specific IGF1R antibodies inhibiting the activation of homodimer IGF1R, but not the insulin/IGF receptor hybrid

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