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Description

Similar to CD4 + T cells, in which LDHA is induced by TCR stimulation [108], antigen-specific CD8 + T cells also upregulate the expression of LDHA upon activation [181]

Causes of Interstitial Cystitis The exact cause of IC is unknown

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Hypoxia induces the overexpression of Hilpda, which leads to triglyceride overload and FAO defects by downregulating adipose triglyceride lipase (ATGL), triggering mitochondrial dysfunction and upregulating profibrotic factors (TGF-1, -SMA, type I collagen) while reducing the expression of cyclin-dependent kinase 1 (CDK1) and increasing the CyclinB1/D1 ratio, collectively promoting renal tubular fibrosis [85]