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Cell Biochem Funct 2004;22:3738

Blocking FoxO1 inhibits profibrotic gene expression by macrophages and reverses peribronchial fibrosis in a murine model of allergic asthma (250)

& Lefebvre, B

Gln depletion treatment activates FADD and caspase-8-dependent apoptosis involving pro-apoptotic TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) in tumour cells, while metabolic stress induced by glutamine deprivation leads to the downregulation of the GCN2-non-dependent FLICE-inhibitory protein (FLIP), which promotes caspase-8 activation and apoptosis [55]