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By activating CB 2 R, CBD inhibits pro-inflammatory signaling pathways such as NF-B, thereby reducing the production of IL-1 and TNF- ( 2 R can effectively reduce HSC activation by inhibiting the NOX4 and NF-B signaling pathway, which in turn lowers the expression of -SMA and slows down the fibrotic process (Xie et al., 2024)

Under sufficient supply of polysaccharide, butyrate-producing bacteria can preferentially utilize nitrogen sources, such as AAs, for synthesizing cellular components and proliferation, rather than for generating harmful protein fermentation products

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