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The role of HK2 has been extensively characterized in various pathological processes, including liver I/R, HCC, and diabetes, where it is often overexpressed and associated with disease progression 69

Weisbord, S

It also exists in a soluble form (sKlotho) which is generated by cleavage of the extracellular domain of -Klotho, which circulates in the blood and also exerts systemic effects, including cardioprotective properties, which are still poorly understood [80, 82]