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However, the clinical relevance of its effects is currently unclear, given the limitations of the studies identified, including the heterogeneity of studies, the number of studies with insufficient power, and other methodologic considerations [100]

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However, he added that since many of these experimental peptides dont have the same robust catalog of clinical trial data as FDA-approved medications, evaluating them for the 503A Bulks List may prove challenging for the committee and the agency

In the present review, NSCLC metabolism was discussed with a focus on the potential of metformin-based targeting of NSCLC metabolism and the associated mechanisms, and the available preclinical and clinical evidence was assessed