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Designing Excited States: Theory-Guided Access to Efficient Photosensitizers for Photodynamic Action

AshwoodPKrakowiakPHertz-PicciottoIHansenRPessahINVan de WaterJ

Several glutathione-dependent enzymatic antioxidant pathways protect the cell from oxidant injury: glutathione peroxidase (GPx) uses GSH as a cofactor to reduce H2O2 and organic hydroperoxides, the overall reaction reducing peroxide molecules to water and oxidatively coupling two glutathiones to liberate GSSG (13)

Groups (3, 4, and 5) received 100 mg/kg silymarin (standard reference), 500 mg/kg NSO, and 250 mg/kg NSS, respectively, and were subjected to the same dose of AZA

Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis