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This combination can improve cognitive outcomes more effectively than either treatment alone

Hand grip was measured six times (three times in each hand) the maximum values were considered as value of hand grip

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Glossary Agrp Agouti-related protein AKT Protein kinase B (AKT) AMPK AMP-activated protein kinase ARC Arcuate nucleus BAT Brown adipose tissue BMI Body mass index cAMP Cyclic adenosine monophosphate C/EBP CCAAT/enhancer-binding protein beta DA Dopamine DLN Dorsolateral nucleus DMN Dorsomedial nucleus D2R Dopamine D2 receptor E2 17-estradiol EGF Epidermal growth factor FSH Follicle-stimulating hormone GAS -Interferon activation sequence GLP-1 Glucagon-like peptide-1 GLP-1 RAs Glucagon-like peptide-1 receptor agonists GnRH Gonadotropin-releasing hormone HDL-C High-density lipoprotein cholesterol HPG Hypothalamicpituitarygonadal (axis) HPRL Hyperprolactinemia ICV Intraventricular (intracerebroventricular) IL-1 Interleukin-1 beta IL-6 Interleukin-6 JAK2 Janus kinase 2 kDa Kilodalton LDL-C Low-density lipoprotein cholesterol LH Luteinizing hormone MAPK Mitogen-activated protein kinase MASLD Metabolic dysfunctionassociated fatty liver disease PY Neuropeptide Y PI3K Phosphoinositide 3-kinase PPAR Peroxisome proliferator-activated receptor gamma PRL Prolactin PRLR Prolactin receptor Ras Rat sarcoma (Ras) signaling family SCN Suprachiasmatic nucleus STAT Signal transducer and activator of transcription TIDA Tuberoinfundibular dopaminergic TNF- Tumor necrosis factor alpha TRH Thyrotropin-releasing hormone