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Specifically, incorporating the 4-1BB costimulatory signaling motif into the CAR design activates signaling pathways that include the NIK/non-canonical NF-B pathway, which enhances T cell persistence and antitumor efficacy [171]

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doi: 10.1016/j.cell.2023.03.011 Summary Keywords microbial-derived metabolites, anti-tumor immunity, chemotherapy, immunotherapy, therapeutic strategies Citation Lu S, Wang C, Ma J and Wang Y (2024) Metabolic mediators: microbial-derived metabolites as key regulators of anti-tumor immunity, immunotherapy, and chemotherapy

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