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This process can alter arginine and lysine residues in lens proteins, causing proteins to clump together and encouraging the formation of advanced glycation end products

1 2 "A synthetic cannabinoid FDU-NNEI, two 2 H -indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N -OH-EDMA, and a cathinone derivative dimethoxy--PHP, newly identified in illegal products"

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Physical dependence is a state that develops as a result of physiological adaptation in response to repeated drug use, manifested by withdrawal signs and symptoms after abrupt discontinuation or a significant dose reduction of a drug