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Nonetheless, there is an ongoing debate over the causative relationship between TMAO and cardiovascular disease, as certain studies have found no connection

Bakalov 2020), skin rash (NatMed 2025, unclear, unknown grading), hypophosphatemia resolved after discontinuation (NatMed2025)

Multiple dosages of ALC administered intravenously and orally increased ALC CSF and plasma concentrations in Alzheimer's disease patients, suggesting that ALC efficiently passes the bloodbrain barrier (BBB) (Parnetti et al., 1992)

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