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To identify miRNAs accumulating in Zswim8 -knockout lines compared with control lines, reads associated with all isoforms of a given miRNA were summed, filtered on the basis of a read cutoff of greater than five reads per library for at least two of the knockout lines and 30 reads across all six lines (three knockouts and three controls) and normalized for sequencing depth using the estimateSizeFactors function of DESeq2 (v.1.38.3) 87

Similarly, intraperitoneal administration of 0.25 mg/kg and 0.50 mg/kg and oral administration of 2.0 mg/kg of Dihexa significantly improved performance to levels comparable with vehicle controls

Bioinformatics 29, 1521

The neuroprotective effect of DMSO observed in this study agrees with other studies reported by (Torre et al., 1973) who first reported the potential therapeutic effect of DMSO in central nervous system injury

Inflammation is a complex response to tissue damage or infection associated with oxidative stress