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LrGG bacteria have the ability to adhere to epithelial cells, promote type 1 immune response, and through inhibiting the activation of macrophages to effectively reduce the inflammatory response, and promote the production of innate immune cells such as IL-10, IL-12, and TNF- ( Lactobacillus reuteri , on the other hand, cooperates in changing the PH of the oral environment through the colony effect and the production of lactic acid and other acidic substances, simultaneous generation of H2O2 to effectively reduce overgrowth and potential toxic effects of Candida in vivo ( 5.2 Oral ulcer-like diseases 5.2.1 Recurrent aphthous ulcer Recurrent aphthous ulcer (RAU), also known as recurrent aphthous stomatitis or recurrent oral ulcer, is the most common oral mucosal ulcer disease that severely affects patients' oral health and quality of life ( Lactobacillus reuteri reduced the severity of aphthous lesions over 90 days, however, there was no advantage compared with placebo and the effective practice of probiotic treatment of RAU was brief ( Bacillus cloacae , therefore, probiotics have been suggested as an adjunct to the treatment of recurrent aphthous stomatitis