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Luzzatto, L., Nannelli, C

In pharmacokinetics studies its excretion was relatively high ranging from 60% to 72% suggesting that its content in the diet is mostly sufficient (Eissenstat et al., 1986

& Shahi, M

These compounds are chemically distinct from peptides in every way

Due to different intracellular and extracellular functions HMGB1 is a central mediator in inflammation and immunity, but its activity depends on the state of its redox-sensitive cysteine residues at positions 23, 45 and 106 ranging from DNA binding, to induction of chemotaxis and transcription of chemokines [197, 198] suggesting its classification as an alarmin for sepsis and cancer [199]