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However, whether patients with PBC are at higher risk of developing osteoporosis than general population is controversial [163,164]

As per the researchers, the addition of lactate increased the flux through the gluconeogenic pathway, and appeared as glucose because the peptide also inactivated glycogen synthase

The significant depletion of PON1 starting from Stage II indicates that oxidative stress becomes a dominant feature with the onset of parenchymal infiltration and granulomatous burden