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Summary The accumulation of irreparable cellular damage restricts healthspan after acute stress or natural aging

Epigenetic dysregulation in PD is further illustrated by the hypermethylation of the PGC1- promoter, a master regulator of mitochondrial biogenesis (27, 195, 196)

In addition, opioid antagonism increases cortisol responses, and this is thought to reflect blockade of a tonic endogenous opioid inhibition of cortisol in humans (Lovallo et al., 2015)