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[21] When treated with cyanocobalamin, patients with Leber's disease may develop serious optic atrophy, possibly leading to blindness, based on few case reports

The 14-day window applies to both the monthly and every-over-month schedule, but having the injections on time is particularly important for those using the every-other-month regimen

This is especially important because the FDA has warned consumers about HCG products marketed for weight loss, particularly those sold as drops, sprays, and other non-prescription formats

Some practitioners even inject a tiny droplet of local anesthetic at the injection site to improve comfort and further reduce bruising risk