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The administration of BPC157 was well tolerated by all dogs, and no visual signs of toxicity were observed, which was consistent with our previous safety evaluation studies

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Furthermore, we identified dysregulation of the methionine cycle and transsulfuration pathway, leading to severe glutathione (GSH) exhaustion and indirect deactivation of glutathione peroxidase 4 (GPx4), a critical enzyme in preventing ferroptosis

Due to its antioxidant properties, it effectively mitigates oxidative stress and promotes muscle regeneration through enhanced myofibrillar proliferation, hence decreasing muscle loss in an animal model of induced muscular atrophy (545)