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This suggests that B12 deficiency has detrimental effects on immune function and myelin production at younger ages [127]

Understanding how CD38 enzymatic activity and adenosinergic metabolism evolve during therapy is essential for improving treatment efficacy

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They exhibit high selectivity towards cancer cells, minimizing off-target effects and reducing toxicity to healthy tissues

proposed a vascular normalization theory in which a judicious intensity of anti-angiogenic therapy could result in an equilibrium between anti-angiogenic and pro-angiogenic signals within the TMEvascular normalization statusand enable efficient delivery of oxygen, drugs, and anti-cancer immune cells into the tumor, rather than inducing excessive destruction of vessels and intratumoral hypoxia 35,36