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PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses PMC The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Mechanism of acetaminophen induced hepatotoxicity. High dose of Download Scientific Diagram Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect
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