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(4) Similarly, the clinical study on models of diabetic neuropathic ulcers reported that GHK-Cu, combined with standard wound care, appeared more impactful for wound closure than standard care alone

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These radicals can directly interact with polyunsaturated fatty acids in the cell and plasma membranes, generating substantial amounts of lipid ROS that induce cell death ( Iron involvement in the visual cycle was discovered by the characterization of the enzyme RPE65, an iron-dependent isomeric hydrolase critical for vision (27)

Importantly, improved cell survival, proliferation, and differentiation were observed, ultimately promoting the overall efficacy of RGC regeneration (Fig