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Journal of Neuroendocrinology

I'm generally fairly happy to trust my judgement on things

However, clinical translation has been challenging due to delivery issues and side effects

Cross-compound receptor-occupancy percentages are deliberately not compared here: occupancy (pRO) is a modeled inference, not a measurement, and Willard 2020 cautions that "calculating pRO values has caveats." Binding affinity is the measured quantity

The study concluded that folic acid enhanced cognition and reduced inflammatory markers, though donepezils presence may have influenced the findings (Table 6) (208)