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Pravastatin Treatment and Antioxidants Supplementation Thirty-day-old male LDLr -/- mice received pravastatin (Medley Ltda, Brazil) diluted in the drinking water (400 mg/L) during 3 months as previously described (Lorza-Gil et al., 2016)

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Consequently, asparaginase (ASNase)-mediated depletion of asparagine inhibits both primary tumor growth and metastasis through mechanisms involving both asparagine deprivation and glutamine depletion (85)