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In vivo, oxidative conditions are frequently generated by ROS and RNS, which are normally tightly regulated by multiple enzymatic systems, among which GSH and GSH-dependent enzymes play central roles [39]

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The limitations of SLNs are their low loading capacity for drugs and the possibility of drug efflux during storage, reducing efficacy

However, some reports evaluating the toxicity of PAP provided findings considering that both glutathione and cysteine conjugates can possess some toxic effects (Klos et al