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At the initial baseline visit, serial venous sampling performed after oral d 3 -l-carnitine challenge revealed rapid increases in plasma concentrations of d 3 -l-carnitine, and subsequent increases in d 3 -BB and d 3 -TMAO following a lag phase (Figure 1, AC, filled circles)

Results from the LMER models with the same effect size direction in the discovery and replication cohorts were then meta-analysed using fixed-effects meta-analysis implemented via the R package metafor (v.4.40)

This pathway is involved in enhancing therapeutic efficacy (e.g., 20(S)-Rg3 combined with sorafenib for hepatocellular carcinoma), reducing toxicity (Astragaloside IV counteracts doxorubicin-induced nephrotoxicity), and reversing drug resistance (Saikosaponin A combined with gemcitabine for intrahepatic cholangiocarcinoma)

[DOI] [PubMed] [Google Scholar] 296.Makrecka M, Kuka J, Volska K, Antone U, Sevostjanovs E, Cirule H, et al

Recognizing the symptoms early and getting necessary medical attention can minimize the severity and duration of episodes