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As a single transmembrane receptor, the low-density lipoprotein receptor (LDLR) plays an important role in maintaining the homeostasis of intracellular cholesterol metabolism, in which exogenous cholesterol is internalized into the low-density lipoprotein (LDL) and taken up by the cell after binding to the LDLR on the cytosolic membrane [198]

However, in GCLM KO mice, genes encoding lipid synthesis enzymes, Fasn and Scd , were further down-regulated, whereas Fads1 was up-regulated by ethanol, the net effect of which would be expected to result in lower levels of total TG and increases in the relative abundance of certain lipid species

However, there is no NICE or NHS recommendation for adolescents aged 12-17

doi: 10.2147/COPD.S135338 124 MaguireJ