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Hence, the efficacy of sorafenib in liver cancer can be enhanced by using GHR as a target ( In vitro and in vivo studies have evaluated the biological functions of GHR in breast cancer by silencing GHR and showed that GHR reduction leads to the inhibition of cell proliferation, the cell-cycle arrest in G1-S phase transition, tumor growth, and cell apoptosis induction of breast cancer cell lines, speculating these effects might be due to the inhibition of the Raf/MEK/ERK signaling pathway (Zhu et al., 2020)