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Critically, BPC-157 alone produced no behavioral or temperature effects, confirming it acts only when the serotonin system is disturbed

Therefore, drugs with a high oral bioavailability are stable in the GI tract, are well absorbed and undergo minimal first-pass metabolism (Figure 2.2)

Real-time quantitative polymerase chain reaction Total RNA was extracted from cells using the Trizol reagent (Takara Bio Inc, Japan) according to the manufacturers instructions